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2nd>Try to detect blood vessels and some gray points.
I use green filter and i tried to detect blood vessels but its precision is bad. So I have add some other algorithms. And I made filter which detect gray point.It works pretty well. But lesser area also detected. So I have to make mask of lesser. If I can make mask of lesser area it almost work well.
3rd>Think about threshold
I tried to make these kind of filter. But its threshold is not automatically. So I have to make some program which get threshold or we have to use same funduscopy.
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